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Shimada R, Nakashima T, Nunoi K, et al "Arrhythmia during insulin-induced hypoglycemia in a diabetic patient.

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There are reduced urinary D-chiro-inositol concentrations in the urine of persons with type II diabetes, gestational diabetes, and PCOS as well as any insulin resistant state that is not necessarily diagnosed; due to this and how increasing urinary concentrations are directly correlated to reduced insulin receptor activity in skeletal muscle, urinary levels of inositol derivatives (D-chiro-inositols and myo-inositols) are seen as a biomarker for insulin resistance.

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Following pioneering work by Bornstein and the Nobel Prize-winning work of Yalow and Berson, the first insulin assays became widely available in the late 1960s; it was subsequently confirmed that diabetic patients with so-called or maturity onset or type 2 diabetes had normal or increased plasma insulin levels.

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PIP 3 (or it could produce diacylglycerol if it doesn't produce PIP 3 ) and anything that inhibits PI3K (such as wortmannin) inhibit insulin-stimulated glucose uptake in part due to inhibiting PIP 3 formation.

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For example, Columbia University scientists claim that by turning off a particular gene, human gut cells can be converted into cells that produce insulin in response to dietary sugar.

While substitution of an NNRTI for a PI to reduce insulin resistance is a reasonable approach, in some cases only a PI will provide sufficient strength.

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During the compensated phase on insulin resistance, insulin levels are higher, and blood glucose levels are still maintained.

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If a pregnant woman eats a high-carbohydrate diet, which turns into sugar, animal studies have shown that the fetus will become more insulin resistant.

Furthermore, adipose tissue expression of these chemokines and receptors correlated positively with increased systemic inflammation and insulin resistance ().

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Wiseman, CE; Higgins, JA; Denyer, GS; Brand Miller, JC (1996).

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Those who started a PI-based regimen had elevated fasting insulin and blood glucose levels, which suggest increased insulin resistance, as well as increased triglyceride and LDL ("bad") cholesterol levels.

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